ABSTRACT
Congenital tuberculosis is a rare disease in which an unborn child inside the uterus or right after delivery is infected with tubercle bacillus, due to the mother suffering primary tuberculosis right before pregnancy or during pregnancy. As a newborn who was naturally delivered with a gestational age of 38 weeks, and 3.02 kg in birth weight, he entered an other hospital with a fever, which he contracted one month after birth, but the fever continued for 10 days, thus he was transferred to this hospital. Chest radiography, indicated infiltration of both lungs, thus he was treated with suspected pneumonia and sepsis. And then, his symptoms became favorable, and he left hospital. However, since chest radiography one month later, his condition had not improved, thus he was hospitalized again. In a computerized chest tomography scan, infiltration of the lungs and tuberculosis were suspected due to a mysterious region of shadow. A tubercle bacillus test was conducted, and the tuberculin test was negative. However, acid- fast bacilli smear, acid-fast bacilli culture test, and polymerase chain reaction test, which were carried out the gastric aspiration were positive. The patient was administered antitubercular agents under the diagnosis of congenital tuberculosis, and he is currently under observation as an outpatient, without complications. The authors experienced a case of congenital tuberculosis, which was discovered due to fever, generated 4 weeks after birth, and to abnormal views in chest radiography, which continued more than 2 months. We report this.
Subject(s)
Child , Humans , Infant , Infant, Newborn , Pregnancy , Antitubercular Agents , Bacillus , Birth Weight , Diagnosis , Fever , Gestational Age , Lung , Mothers , Outpatients , Parturition , Pneumonia , Polymerase Chain Reaction , Radiography , Rare Diseases , Sepsis , Thorax , Tuberculin Test , Tuberculosis , UterusABSTRACT
PURPOSE: Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease with complex clinical manifestations. It probably involves genetic, environmental and immunologic factors. In this study, we investigated the clinical manifestations, laboratory findings and prognosis of pediatric SLE to aid clinical care of pediatric SLE. METHODS: The data of 45 patients who were diagnosed as pediatric SLE in Severance Children's Hospital from Jan. 1996 to Dec. 2005 were analysed retrospectively. RESULTS: The mean age at diagnosis was 10.8 (0-15) years old. And the ratio of male to female patients was 1:4. The initial manifestations were facial edema (51.1 percent), malar rash (44.4 percent), and fever (28.9 percent). The ANA (97.8 percent), anti-ds DNA antibody (82.2 percent), lupus nephritis (71.1 percent), malar rash (71.1 percent), and cytopenia (66.7 percent) were the most common findings among the classification criteria by ACR (American College of Rhematology, 1997). CONCLUSION: Clinical manifestations and prognosis are various in pediatric SLE. Intensive studies of SLE in children should be continued for more effective treatment.
Subject(s)
Adolescent , Child , Female , Humans , Male , Autoimmune Diseases , Classification , Diagnosis , DNA , Edema , Exanthema , Fever , Immunologic Factors , Lupus Erythematosus, Systemic , Lupus Nephritis , Prognosis , Retrospective StudiesABSTRACT
PURPOSE: The prevalence of asthma and allergic diseases is on the increase and that of obesity is on the continuous increase all over the world. There are recent studies on the association between asthma and obesity, which are still controversial. This study aimed at identifying the effect of obesity on atopy and bronchial hyperresponsiveness in children. METHODS: This study was conducted with 443 subjects ranging from six to 15 years of age, and consisted of 283 boys and 160 girls. They went through pulmonary function tests and methacholine challenge tests with their eosinophil counts within blood, total serum IgE levels, serum eosinophil cationic protein(ECP) levels, heights, and weights measured. After determining body mass index(BMI), BMI percentiles were determined by using a BMI percentile curve based on gender and age. After the classification on the basis of the 85th, 90th, and 95th BMI percentiles, a comparison was made in frequencies of atopy, total serum IgE, eosiniphil counts within blood, and serum ECPs as well as in frequencies of bronchial hyperresponsiveness for the total group, the boys, and the girls, respectively. RESULTS: Among the groups classified by BMI percentiles, there was no significant differences in total serum IgE, eosinophil counts within blood, and serum ECPs. There also was no significant differences in bronchial hyperresponsiveness or pulmonary functions among them. Effect of atopy and pulmonary function test variables on BMI did not show any statistical significance in boys, girls or the total group. CONCLUSION: There was domestically no association between obesity and atopy and bronchial hyperresponsiveness among children.